Method for analyzing signaling networks in complex cellular systems
نویسندگان
چکیده
منابع مشابه
Method for analyzing signaling networks in complex cellular systems.
Now that the human genome has been sequenced, the challenge of assigning function to human genes has become acute. Existing approaches using microarrays or proteomics frequently generate very large volumes of data not directly related to biological function, making interpretation difficult. Here, we describe a technique for integrative systems biology in which: (i) primary cells are cultured un...
متن کاملComplex networks theory for analyzing metabolic networks
One of the main tasks of post-genomic informatics is to systematically investigate all molecules and their interactions within a living cell so as to understand how these molecules and the interactions between them relate to the function of the organism, while networks are appropriate abstract description of all kinds of interactions. In the past few years, great achievement has been made in de...
متن کاملPredicting and Analyzing Cellular Networks
Predicting and Analyzing Cellular Networks Proteins accomplish virtually all of their cellular functions via interactions with other molecules. As a result, a broad array of computational methods have been developed to predict protein interactions, whether with DNA, other proteins, or small molecules. In combination with high-throughput experimental technologies, we now have the ability able to...
متن کامل[Article] Perturbation Biology: Inferring Signaling Networks in Cellular Systems
We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series of perturbations of cancer cell lines by targeted drugs, singly or in combination. The response to perturbation is quantified in terms of r...
متن کاملPerturbation Biology: Inferring Signaling Networks in Cellular Systems
We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series of perturbations of cancer cell lines by targeted drugs, singly or in combination. The response to perturbation is quantified in terms of r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0308221100